Topic: sensorimotor deficits

Cerebral palsy (CP) is a neuromotor disorder resulting from brain lesions occurring in fetuses or around birth, affecting white matter and leading to sensorimotor deficits. While motor functions have been extensively studied, motor planning deficits in children with CP remains largely unexplored. This study aims to compare anticipatory force control between children with CP and typically developing children (TD) and to investigate the relationship between motor planning tracts (i.e., corticocerebellar tracts) and motor planning deficits. Ten children with CP (7 girls, 3 boys) aged 8-14 years w

Huntington’s Disease (HD) is a neurodegenerative disorder characterised by severe motor disturbances resulting from neural network alterations, particularly evident in deficits in oculomotor functions during the prodromic stage. The superior colliculus (SC) plays a crucial role in integrating visual perception and oculomotor functions, and recent observations in the R6/1 HD mouse model from our group indicate affected connectivity between the M2 motor cortex (M2) and SC. To comprehensively assess changes in HD pathophysiology, we conducted fMRI-based functional connectivity analysis in 17-week

Subarachnoid hemorrhage (SAH) triggers neuroinflammation including the recruitment and activation of immune cells. T-cells in particular, have been shown to promote the evolution of secondary injury following ischemic stroke, however their role in SAH is still unclear.In this study we aimed to evaluate T-cells’ recruitment in the brain of SAH-injured mice to next investigate their specific role in injury progression.Adult C57BL/6J mice were subjected to SAH by blood injection in the prechiasmatic cistern or sham procedure and sacrificed at 3 or 7 days-post-injury (dpi). Sensorimotor deficits w

Inborn errors of immunity (IEI), also known as primary immune deficiencies, are rare diseases caused by distinct pathogenic genetic variants, affecting approximately 1 in 25,000 people. While IEI are primarily associated with increased susceptibility to infection, autoimmunity, and cancer, recent clinical research indicates their impact extends to multiple systems, including the brain. Specifically, activated PI3K-Delta Syndrome (APDS), a rare genetic disorder resulting from mutations in the Pik3cd gene encoding the PI3Kδ enzyme, has been recently linked to neurodevelopmental disorders (NDD).O