Topic: sensorimotor function

Understanding the basal ganglia's role in initiating and executing action sequences is crucial for treating Parkinson's disease (PD). Recent experimental data challenge the classical model attributing pro- and anti-kinetic functions to direct and indirect pathways of the basal ganglia. To better understand movement-related neuronal activity in the basal ganglia, we performed large-scale electrophysiological recordings with Neuropixels probes in awake, behaving mice in the dorsomedial and dorsolateral striatum (DMS and DLS, respectively). We used the MitoPark mouse, a genetic model of PD, to in

Clinical intervention for ischemic stroke patients is limited to the acute phase, leaving ~80% of stroke patients without effective pharmacological intervention and unsatisfactory neurological outcome. Therefore, subacute therapeutics that resolve thrombosis and inflammatory processes to support tissue recovery are urgently in need. Plasma kallikrein (PK), a member of the kallikrein-kinin-system, promotes vascular damage, inflammation, and thrombosis. We hypothesize that prolonged PK activation determines stroke severity and impairs tissue recovery. Thus, wild-type mice were subjected to 60 mi