Topic: sertraline

This study investigated the effects of pharmacologically distinct conventional antidepressants (amitriptyline, moclobemide, sertraline) and modulation of affective biases in rats. We tested each antidepressant in three different affective bias protocols (new learning protocol and modulation of negative affective biases associated with past experiences) and a reward learning assay (RLA) control. The affective bias test (ABT) requires animals to learn two independent and equal reward-value associations following control or drug treatment Any affective bias generated is quantified during a subseq

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra. Neuronal cells, once impaired, do not undergo spontaneous regeneration; consequently, the disease persists beyond the onset of symptoms. There is a growing recognition of the need for treatments that could protect neurons and potentially modify the disease course because current PD treatments primarily address symptoms without halting the disease progression. Autophagy, a cellular process clearing damaged organelles and proteins, has emerged as a poten