Topic: SETD5

Autism spectrum disorder (ASD) affects approximately 1 in 36 individuals, imposing lifelong challenges on patients. Yet still, effective treatments for ASD remain elusive. Rare mutations in the SETD5 (SET Domain Containing 5) gene, a chromatin regulator, have been firmly linked to ASD with high confidence. To date, reports studying the molecular role of SETD5 are limited and how exactly SETD5 haploinsufficiency leads to ASD remains unclear. Setd5-haploinsufficient mice have successfully demonstrated ASD-like behaviours, yet they fail to accurately replicate human brain development and patholog

Animal survival depends on effective predator avoidance mechanisms. However, an innately threatening stimulus may prove non-threatening, allowing the animal to ignore it over time. Such adaptation is exemplified by the learned suppression of escape (LSE) paradigm, in which animals adapt to repeated threatening stimuli. Neuromodulation, and more specifically serotonin modulation has been implicated in the expression and modulation of defensive responses. However, its role in the LSE remains unknown. Recently, we observed an upregulation of the serotonin biosynthesis pathway in the dorsal periaq