Sleep architecture

Mansi Chhajed examines how the move from home sleep patterns to disrupted hospital sleep relates to cognitive outcomes after surgery. The session combines longitudinal sleep measurements with clinical assessments of postoperative delirium to identify baseline markers of vulnerability and consider practical ways to improve recovery. It connects sleep architecture, biological and environmental influences, and preoperative risk with proactive, sleep-informed patient care. Chhajed is a Clinical Research Coordinator at Massachusetts General Hospital. Online via Zoom Webinar. Tuesday 29 September 2

Temazepam is a widely used insomnia drug, which normalizes sleep architecture and enhances slow-wave sleep. Our study aimed to showcase two methods of explaining a sleep-EEG classification model, in the input and representation space. The goal was to evaluate the effectiveness of these explanations in studying the influence of temazepam on sleep architecture. We fine-tuned BErt-inspired Neural Data Representations (BENDR) encoder pretrained on the TUH EEG Corpus dataset to sleep stage classification. The obtained (sleepBENDR) model is explained using Class Activation Mapping (CAM), which indic

Sleep is present throughout the animal kingdom, but its function remains to be fully determined. Rapid eye movement sleep (REM) is characterised by muscle atonia, heightened theta oscillations, and the occurrence of ponto-geniculo-occipital (PGO) waves or P-waves. The pedunculopontine and laterodorsal tegmental nuclei (PPT/LDT) have been implicated in REM sleep generation, and their cholinergic neuronal activity was specifically associated with P-waves. However, the precise role of pontine cholinergic neurons in REM sleep remains elusive, particularly their impact on sleep architecture and P-w

…a strong link between ELS and poor sleep quality. Poor sleep correlates with increased risk of psychiatric disorders such as anxiety and vulnerability to stress. In this study, we investigated ELS effects on sleep architecture and spindle activity in mice. Two groups were used: ELS group experienced maternal separation for 3 hours daily from postnatal day 1-14, and a stress-naive control group. At the 8 weeks age, EEG and EMG electrodes were implanted for sleep recording. While wake and NREM sle

Hypocretin(orexin)-producing neurons in the lateral hypothalamic area are important for sleep regulation and their damage manifests clinically as narcolepsy in humans. In animal experiments, extensive lesions of these neurons confirmed and clarified their physiological importance. Smaller, partial lesions of hypocretinergic neurons may uncover more subtle mechanisms of function of hypocretin system and may help understand more delicate processes in early stages of pathogenesis of narcolepsy. In a lesioned group of rats (N=9) bilateral injections of hypocretin-2-saporin (Hcrt2-SAP) conjugate in

The onset of Alzheimer disease (AD) and of abnormal sleep patterns are both signaled by initially minute but ultimately disastrous physiological malfunctions of the brain. Among these, the Locus Coeruleus (LC) belongs to the primary brain areas that show such malfunctions in the early stages of AD. The LC generates large noradrenaline (NA) signals that are key for the architecture of sleep in mice. In contrast, how LC malfunctions relate to sleep disturbances in AD remains unknown.We explore the real-time functionality of the noradrenergic system during AD’s prodromal phase in an established A

Sleep quantity and quality change dramatically across the lifespan of altricial mammals born with immature brains such as humans and rodents (Logan 2019, Cirelli 2020, Blumberg 2005, Blumberg 2014). Despite a crucial role for healthy development, we still know quite little about developmental sleep – especially when it comes to architecture and oscillatory dynamics, or to the emergence of global inter-regional brain cross-communication. Current methods to analyse immature sleep fail to provide the resolution needed to characterise its longitudinal microstructure. We designed light-weighted chr

The circadian rhythm and sleep architecture of senescence-accelerated mice (SAM)P8 and SAMR1 were evaluated to utilize SAM as a model of age-related sleep disorders. The evaluation of the circadian rhythm based on the locomotor activity was performed from 1 to 5 months old SAMP8 and SAMR1. At 6 months of age, mice were chronically implanted with electroencephalograph and electromyogram electrodes for polysomnographic recording of sleep-wake states. The vigilance states were automatically classified by SleepSign ver.3 software. First, the circadian rhythm was evaluated. Comparing the locomotor

…effects, one of which is its impact on sleep. The impact of DBS on sleep architecture, circadian rhythms, and other various sleep issues is not well understood. This paper will evaluate peer-reviewed publications on the effect of DBS on sleep, the mechanisms, and the effects for the patients. The conclusion of these questionnaires is