Sleep disturbances

In many neurological disorders, sleep disturbances and intellectual disability are strongly associated.Therefore, by studying these types of disorders, we can attempt to elucidate molecular and cellularmechanisms with broad relevance to brain function and disease. Christianson syndrome (CS) is anexample of a monogenic condition involving X-linked intellectual disability and sleep disturbances.The lack of treatment options for these children is directly related to our poor understanding of themechanisms underlying the disease. CS arises from mutations in the SLC9A6 gene which encodes theendosom

Sleep disturbances are commonly linked with and constitute fundamental characteristics of anxiety disorders. However, the effects of actively increased sleep, especially slow wave sleep (SWS), after social defeat stress, on emotion regulation remain unexplored. By inducing time-locked SWS in mice by optogenetically stimulating the SWS promoting center in Vgat-ChR2-eYFP mice, we provide a direct approach to analyze the influences of SWS on anxiety-like behavior. Here we report that SWS induced by photostimulation immediately after social defeat prevents the development of anxiety disorder. We a

…NF1 are also at increased risk for sleep disturbances. The human NF1 gene (17q11.2) encodes neurofibromin, a 2818-amino-acid protein expressed in various nervous system cells throughout life. Nf1 best-understood and evolutionarily conserved role is as a GTPase Activating Protein (GAP) for Ras, which r

…factors for cognitive decline, with sleep disturbances gaining attention especially in older adults with mild cognitive impairment (MCI). Given the significant impact of sleep disturbances on cognitive decline in MCI, this study explores the relationship between psychological factors, including depression, anxiety, and stress, and insomnia among older adults with MCI. 145 Greek older adults were recruited from an outpatient memory clinic in Athens. The sample m

…Sleep disturbances in AD are linked to amyloid beta, yet the influence of tau pathology on sleep remains unexplored. Using Drosophila melanogaster, we investigated adult-onset tau expression effects on sleep, addressing the knowledge gap in tauopathy's impact on sleep-related changes in AD progression. Pan-neuronal expression of wild-type tau and pseudo-phosphorylated tau E14 in Drosophila was induced in adult flies by RU 486 and activity and sleep were monitored in an automated Drosophila Ac

…on epileptogenesis and associated sleep disruptions. Methods: Our hypothesis proposed a pivotal role for PIP3 in the molecular mechanism of seizures. We intraperitoneal administered low dose of PTZ once every two

Circadian disruption, notably sleep disturbances, serves as an early indicator of Alzheimer’s disease (AD), preceding symptoms like memory loss. The suprachiasmatic nucleus (SCN) governs biological rhythms and receives direct retinal input via melanopsin-expressing retinal ganglion cells (mRGCs) to synchronize with environmental light cycles. The anatomical and functional basis for circadian disruption in AD remains unclear. Here, we explore the relationships between non-visual photoreception, SCN connectome evolution, and sleep regulation in the APP/PS1 mouse model.We measured mRGCs' light-in

…and induce severe symptoms, notably sleep disturbances. Disrupted sleep triggers systemic pro-tumor effects in various cancers. Our research explores the pro-tumor impact of disturbed sleep and potential pathophysiological effects of the brain lesion on sleep ability in our patients, and as indicated by the available literature. To assess sleep quality of patients with neuroradiologically proven brain tumors, participants completed The Pittsburgh Sleep Quality Index questionnaire. After obtaining the pathological diagno

…Sleep disturbances have been ascribed to respiratory insufficiency, muscle cramps, spasticity, or restless legs syndrome, all leading to increased wakefulness. However, a recent neuropathological study in ALS patients described a loss of orexin-producing neurons, a neuropeptide involved in sleep and metabolic regulation, undermining the idea that sleep alterations are linked to central and peripheral changes. Yet, sleep alterations are poorly characterized in ALS, and their rela

…these non-motor symptoms including sleep disturbances and olfactory defects using large collections of knock in fruit flies that model the numerous familial forms of Parkinson’s disease as well as using human iPS cells from patients. A common emerging theme are defects in protein homeostasis