Topic: SOD2

ePoster: 2 ePosters

FoxO1 induced by alpha-synuclein preformed fibrils regulates ROS by expressing antioxidant genes in microglia

Jiyeon Na, Hyeguk Ryu, Hyeonwoo Park, Eunmin Lee, Hyerynn Kim, Haeun Park, Younwoo Nam, Sangjune Kim · FENS Forum 2024

Parkinson's disease (PD) is a multifaceted neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, predominantly within the substantia nigra pars compacta (SNc) region. Dysregulation of FoxO1 has been implicated in various neurodegenerative diseases, including Alzheimer's disease and PD, yet the precise underlying mechanisms remain largely elusive. In this study, we investigated the impact of α-synuclein pre-formed fibrils (PFF) treatment on BV-2 microglial cells to elucidate alterations in molecular properties and neuronal degeneration. Surprisingly, our find

ePoster · Neuroscience

Osteogenesis imperfecta: A look into the brain of a murine model

Enrico Pelloni, Claudio Casali, Roberta Besio, Gloria Milanesi, Wendy Perez Franco, Federica Gola, Ludovica Gaiaschi, Margherita Cavallo, Antonella Forlino, Maria Grazia Bottone, Fabrizio De Luca · FENS Forum 2024

Osteogenesis imperfecta (OI) is a complex disease caused by changes in connective tissue composition, leading to bone fragility. The pathophysiology of this disorder is highly diverse, involving a range of genetic variables and a variety of phenotypic symptoms, including neurological impairment.Our research focused on the possible alteration that occurred in the Central Nervous System (CNS) of an in vivo model of OI, using male and female adult Brtl-/+ mice. Histochemical techniques were employed to investigate the morphological changes of CNS, through Hematoxylin & Eosin and Picrosirius r

ePoster · Neuroscience