Topic: SorLA

The Vps10p-Domain (Vps10p-D) receptor family consists of Sortilin, SorLA, SorCS1, SorCS2 and SorCS3. They mediate internalization and intracellular sorting of specific cargo in various cell types, including neurons, but underlying molecular determinants are incompletely understood. Deciphering the dynamic intracellular itineraries of Vps10p-D receptors is crucial for understanding their role in physiological and cytopathological processes. However, studying their spatial and temporal dynamics by live imaging has been challenging so far, as terminal tagging with fluorophores presumably impedes

VPS10P domain receptors are intracellular sorting receptors which direct their protein cargo to destined subcellular localizations. Although it seemed that functions of VPS10P receptors in the brain are restricted to neurons, it turned out they are also relevant for glial cells, including microglia, which dependently on pathological context may acquire different functional properties. For instance, during glioblastoma progression, microglia along with infiltrating macrophages are reprogrammed, so instead of fighting with glioma they support it, mainly through secretion of pro-tumorigenic facto