Topic: spatial recognition memory

Cognitive impairment is a risk factor for falls, particularly true in the elderly due to age-related decline. Chronic drug consumption, often encountered in elder, has been reported to increase this risk, although underlying mechanisms remain to be uncovered (cumulative effect due to chronic use or increased half-life/higher sensitivity). Among opioid drugs mostly prescribed in elderly within European countries, tramadol is associated to risk of falls. Herein, we investigated the different types of cognitive processes affected after acute or chronic tramadol administration. We conducted a 6-we

Pain is a complex sensory and emotion experience that typically facilitates a learning event so that an individual may avoid future harm. However, in a chronic pain context, pain that is experienced at inappropriate times no longer provides a useful function and may impair learning. Cognitive deficits including difficulties with learning and memory recall have been well documented in the clinic but pre-clinical data is lacking and the neural basis remains poorly understood. Using a chronic constriction injury (CCI) model of neuropathic pain in mice, combined with ex vivo electrophysiology and