Topic: Spatial remapping

The medial enthorhinal cortex (MEC) is a core brain region involved in spatial navigation, and provides navigational information to the downstream hippocampus. Neurons in the MEC respond to an animal's location and heading direction in an environment, as well as boundaries and an animals' distance from objects. Other studies have demonstrated that MEC neurons respond to more than navigation, illustrating the flexibility of the region in adjusting response profiles in different contexts. However, it remains poorly understood under what conditions and at what time-scale changes in MEC coding occ

In volatile environments, humans and animals face different forms of uncertainty to which they must adapt to thrive. However, our understanding of the neural basis of this adaptation is incomplete, despite, for instance, long-standing arguments about its possible dependence on neuromodulation. Here, we take advantage of the well-known spatial remapping of hippocampal place cells in the face of environmental change to interrogate these processes. We performed calcium imaging in CA1 place cells using a new Uncertain Reward virtual reality Task (URTask), in which mice run along a linear track and