Topic: structural alignment

Investigate whether conserved protein structures can improve phylogenetic inference for deeply diverged or rapidly evolving sequences. The workflow retrieves predicted structures, evaluates homology and alignment quality, and combines amino-acid and Foldseek 3Di representations for likelihood-based trees. Exercises compare structural alignment tools, evolutionary models, information criteria and distance methods, then visualise and statistically compare trees. Discussions examine assumptions and limitations of structure-based evidence. Live sessions: 2, 4, 5 and 6 November, 08:00–12:00, Europ

In human and non-human animals, conceptual knowledge is partially organized according to low-dimensional geometries that rely on brain structures and computations involved in spatial representations. Recently, two separate lines of research have investigated cognitive maps, that are associated with the hippocampal formation and are similar to world-centered representations of the environment, and image spaces, that are associated with the parietal cortex and are similar to self-centered spatial relationships. I will suggest that cognitive maps and image spaces may be two manifestations of a m