Structural Phylogenetics: Putting Protein Structure into Phylogenetic Inference

Investigate whether conserved protein structures can improve phylogenetic inference for deeply diverged or rapidly evolving sequences. The workflow retrieves predicted structures, evaluates homology and alignment quality, and combines amino-acid and Foldseek 3Di representations for likelihood-based trees. Exercises compare structural alignment tools, evolutionary models, information criteria and distance methods, then visualise and statistically compare trees. Discussions examine assumptions and limitations of structure-based evidence.

Live sessions: 2, 4, 5 and 6 November, 08:00–12:00, Europe/Madrid (CET, UTC+01:00). Total 22 hours: 16 live plus six independent.

English-language live online course; Fee €560; Ambassador Institution rate €448. VAT included. Capacity: 15. R experience is expected and Unix familiarity is helpful. Participants install the listed analysis and visualisation software before the course. Registration requires acceptance; payment follows confirmation. Recordings are provided, but live attendance is required for a certificate.