Structural variants

…The research asks how structural variants, especially copy number variation (CNV), contribute to novel and potentially adaptive gene expression in hybrids. The lab is collecting data on yeast hybrids and their founder strains under several stress conditions and after induced rounds of meiosis. The researcher will analyse CNVs and their genomic p

…quality, and filter and annotate structural variants. Participants build trio or population VCF datasets, examine mosaic and somatic variation, and prioritise possible functional effects using human-genome examples. Linux and cloud exercises connect raw data processing with interpretation of disease and phenotype associations. Sessions: 30 November–2 December, 14:00–20:00 daily, Europ

…The laboratory studies how structural variants, repetitive DNA and other genetic variation shape phenotypes through effects on gene regulation, genome function and organismal traits. The associate will lead independent projects that can combine molecular biology, genetics, functional genomics, population genomics, pangenomics, genome engineering, computational biology and bioinformatics, with the experimental-c

…Structural variants appear in both clinical and general-population cohorts. Their effects are considered through variable expressivity and through direct or indirect influences on multiple traits.