The SIMple microscope: Development of a fibre-based platform for accessible SIM imaging in unconventional environments
Rebecca McClelland · PhD student at the University of Cambridge, United Kingdom.
Tue, Aug 26, 2025 · 06:00 UTC
Advancements in imaging speed, depth and resolution have made structured illumination microscopy (SIM) an increasingly powerful optical sectioning (OS) and super-resolution (SR) technique, but these developments remain inaccessible to many life science researchers due to the cost, optical complexity and delicacy of these instruments. We address these limitations by redesigning the optical path using in-line fibre components that are compact, lightweight and easily assembled in a “Plug & Play” modality, without compromising imaging performance. They can be integrated into an existing widefield