Subcortical structures

…representations in cortical and subcortical structures. Presentation of four differ

…literature highlights the key role of subcortical structures in brain dynamics and cognitive processes. We investigated cortico-subcortical interactions in the human brain at rest by analyzing dynamic functional connectivity at rest in a large cohort of healthy human participants.Methods. We considered 1078 human participants from the Human Connectome Project, for which resting-state fMRI scans were available. We computed sliding window functional connectivity (sw-FC) on windows of 60 s. sw-FC matrices were appro

…Working with neural recordings from subcortical structures involved in regulation of survival behaviors, we show how the dynamical properties of neural populations give rise to motivational states that change animal behavior on a timescale of min

…binocularly, both in the cortex and in subcortical structures that govern pupil diameter. Here I will describe the results of experiments using a novel combined EEG and pupillometry paradigm to simultaneously index binocular combination of luminance flicke

Historically, retinotopic organisation (the spatial mapping of the retina across the cortical surface) was considered the purview of early regions of visual cortex (V1-V4) only and that anterior, more cognitively involved regions abstracted this information away. The contemporary view is quite different. Here, with Advancing technologies and analysis methods, we see that retinotopic information is not simply thrown away by these regions but rather is maintained to the potential benefit of our broader cognition. This maintenance of visuospatial coding extends not only through visual cortex, but

…from medial frontal regions down to subcortical structures up to a depth of 20 mm. It is a method for imaging transient changes

Background: Recent discovery of hundreds of common gene variants associated with schizophrenia has enabled polygenic risk scores (PRS) to be measured in the population. It is hypothesized that normal variation in genetic risk of schizophrenia should be associated with MRI changes in brain morphometry and tissue composition. Methods: We used the largest extant genome-wide association dataset (N = 69,369 cases and N = 236,642 healthy controls) to measure PRS for schizophrenia in a large sample of adults from the UK Biobank (Nmax = 29,878) who had multiple micro- and macro-structural MRI metrics

…as a result of inputs to cortex from subcortical structures that release neuromodulators such as acetylcholine, noradrenaline, and serotonin, often non-synaptically. The mechanisms that underlie the interaction between these “wireless” non-synaptic signals and the “wired” cortical circuit are not well understood. Furthermore, neuromodulatory signaling is traditionally conside