Subgenual anterior cingulate cortex

…including the dorsolateral prefrontal cortex (dlPFC), subgenual anterior cingulate cortex (sgACC), pregenual anterior cingulate cortex (pACC) and striatum, is involved in MDD. Further, neural manipulations of the dlPFC and sgACC show promise in alleviating MDD symptoms. In non-human primates, beta-band oscillatory activity in the striatum correlat

Weighted Gene Co-expression Network Analysis (WGCNA) is a widely used bioinformatics method that defines gene clusters (modules) based on correlated expression levels, allowing users to study relationships between modules, define groups of genes subserving common biological functions, and compare network topologies across distinct sets of expression data. WGCNA overcomes many challenges of gene-based studies, but it remains difficult to compare WGCNA results across studies, since gene modules are highly dependent on user parameters, experimental conditions, and other variables. As such, no con