Topic: suicidal behavior

Altered functional connectivity in human brain networks has been reported in mood disorders. A moderating hub between resting state networks (RSNs) and the medial temporal lobe (MTL) is the parahippocampal cortex (PHC), where abnormal activity has been reported in depressed patients and suicide attempters. Alterations in neuronal mitochondrial function may contribute to depression and suicidal behavior, however, little is known about the underlying molecular level changes in relevant structures. Specifically, expressional changes related to suicide have not been reported in the PHC. Here, we c

Major depressive disorder (MDD) is one of the most common psychiatric disorders. Very difficult to treat, this disease is one of the leading causes of suicide. A recent study showed an association between GPR56/ADGRG1 mRNA, MDD and response to antidepressant treatment in blood and in brain. Among GPR56 transcript isoforms, the S4 isoform has recently been associated with microglial synaptic pruning, while microglia are already known as a central player in MDD. Therefore, we hypothesize that S4 is the specific isoform associated with MDD and antidepressant response. To test our hypothesis, an i