Superoxide dismutase

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, following Alzheimer's disease. It is characterized by the degeneration of dopaminergic neurons in the SNpc, resulting in both motor and non-motor symptoms. Current treatments are limited, and PD's molecular basis involves alpha-synuclein aggregation, ubiquitination dysregulation, and oxidative stress. Nicotine, found in tobacco, has been associated with reduced PD risk in epidemiological studies and shown neuroprotective effects in animal models. However, its impact on oxidative stress remains unclear. A study in

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, defined by motor neuron loss, muscle paralysis, and death. ALS individuals often present alterations in cardiovascular function that may evolve into heart failure and death. Mitochondrial dysfunction and oxidative stress are key players in ALS pathophysiology. Thus, improving mitochondrial function and/or antioxidant capacity constitute promising therapeutic strategies to delay ALS progression. We hypothesized that mitochondria-targeted antioxidant AntiOxCIN4 can reduce cardiac oxidative/nitrosative stress in SOD1G93A ALS mice