Topic: synaptic proteome

Establishing, maintaining and dynamically modifying synaptic connections is a key principle of neuronal computations. The underlying molecular resource of these processes is synaptic proteins. Tight control of protein levels across neurons is crucial to ensure synaptic function. Changes in the synaptic proteome have been associated with compromised synaptic function and in severe cases various diseases. Among the major factors in regulating protein levels are thought to be protein synthesis, trafficking and degradation. While there is substantial literature on protein synthesis, both trafficki

The serine-threonine kinase Ndr2 controls axonal and dendritic growth in vertebrates and invertebrates. Further work from our group has shown that Ndr2 KO mice display deficits in synapse development, and plasticity, that lead to spatial memory impairment. Moreover, the Ndr family of kinases have recently been implicated in the regulation of autophagy, which is essential for memory formation and cognitive function during ageing. Nonetheless, the question of whether Ndr2 is involved in age-related autophagy dysregulation and the cognitive decline associated with it remained. In the current stud