Topic: systemic lupus erythematosus

Systemic lupus erythematosus (SLE) often impacts brain function, causing cognitive impairment and psychiatric disorders, referred to as neuropsychiatric SLE (NSLE). This research compares the neuronal morphology of SLE mouse models (NZB/W F1) and wild-type (WT) mice in the hippocampus, a brain area exhibiting significant effects from NSLE. Nissl-stained sections were processed via a deep learning method to outline individual cells, with and without Calcium Binding Proteins (CBPs). Morphological and density features were extracted at the cellular level, and cells were classified into distinct s