Topic: tau hyperphosphorylation

Progressive impairment of cognition is a key clinical feature of Alzheimer’s disease (AD), characterized by the accumulation of amyloid beta-protein (Aβ), tau hyperphosphorylation, neuroinflammation, and neuronal degeneration.Cannabidiol (CBD) is a safe, non-psychoactive phytocannabinoid that exhibits immunomodulatory activity in neurodegenerative disease, may ameliorate AD symptoms and slow cognitive decline.In this study, we aimed to examine whether chronic treatment with CBD can prevent cognitive and social deficits in a rat model of sporadic AD, and whether these changes are associated wit

Alzheimer Disease (AD), the most common neurodegenerative disease in elderly has been recently associated with the consumption of high fat diets in which Palmitic Acid (PA) is one of the principal components. Recent studies have shown that neurons can metabolize PA through β-oxidation leading to an increase in ATP levels, decrease in NAD+ concentration and reduced Sirtuin 1 expression and activity. These processes converge on the regulation of different signaling pathways that could regulate and impact posttranslational modifications (PTMs) of tau protein. To elucidate the kinases involved in