Topic: telomere attrition

Neurodegenerative diseases are the most prevalent age-related pathologies, including Alzheimer’s disease (AD). Recent studies suggest that telomere attrition, the main trigger of cellular senescence and pathological ageing may contribute to brain dysfunction and neurodegeneration. Senescent brain cells have been observed in AD brains, and studies in a transgenic mouse model of tauopathy found that the elimination of senescent cells led to an improvement in neurodegeneration and cognitive decline. In this project, we aim to unravel the relationship between brain senescence and the onset and pro

Aging is the main risk factor for Alzheimer’s disease (AD), a prevalent and devastating neurodegenerative pathology with no effective cure. Research efforts aimed at understanding the link between pathological aging (senescence) and AD are crucial for developing pharmacological therapeutic strategies. Mitochondrial dysfunction and mitophagy defects are observed during senescence and AD, and studies suggest that they might lead to Aβ accumulation. Our goal in this project was to explore if a reduced removal of dysfunctional mitochondria during aging is a key contributor to amyloid pathology and