Topic: transcriptomic profiles

Autism Spectrum Disorder (ASD) is characterized by impairments in social communication and interactions, as well as restricted behaviours. Strikingly most of ASD patients also exhibit aberrant reactivity to sensory stimuli including tactile stimuli. Tactile information is perceived in the periphery and processed in the spinal cord under the control of inhibitory neurons before being sent to higher brain structures. However, whether these inhibitory neurons undergo functional alterations in ASD models remains poorly investigated. To explore the functional plasticity of those neurons in ASD, we

Corpora amylacea (CAs) are a type of polyglucosan bodies that are generally found in a variety of organs during aging, including the human brain. While CAs in the human brain mainly consist of abnormal glycogen molecules, they also contain a set of proteins including Ubiquitin and p62, which are usually involved in cellular degradation pathways. The abundance of CAs is strikingly increased in neurodegenerative conditions such as Alzheimer’s disease (AD), suggesting that the occurrence of CAs might either be a protective mechanism or a co-morbidity in the aging human brain. To understand the fo

Microglia, tissue-resident macrophages of the brain, are strongly involved in the maintenance of brain homeostasis. Genome-wide association studies have established their critical role in the pathogenesis of Alzheimer’s disease (AD) but their precise contribution is not yet clarified. Most AD preclinical studies are performed in transgenic mouse models. However murine and human microglia have different transcriptomic profiles with aging. Interestingly, induced pluripotent stem cells (iPSCs) – derived models enable studying human-like cells. Our project aims to generate human iPSCs-derived micr