Topic: translating ribosome affinity purification

Neuronal networks require precise coordination of excitatory and inhibitory synaptic connectivity to function properly. Regulation of parvalbumin-positive (PV+) interneuron activity is especially important for network function, and changes in PV+ interneuron activity correlate with an animal’s performance in learning tasks. Previously, changes in PV+ interneuron connectivity have been shown to regulate excitatory pyramidal cell activity. However, the mechanism via which PV+ interneurons control their own activity remains unknown. Here we used a chemogenetic approach to change the activity of P

Neuropathic pain is evoked by an injury to the somatosensory system at the peripheral or central nervous system level leading to direct changes in neuronal activity. Moreover, there is a large body of evidence that changes occurring in primary peripheral sensory neurons also alter secondary central circuits thus causing hyperalgesia and allodynia. The latter are hallmarks of neuropathic pain and recent work suggests that both of those sensory abnormalities depend on alterations in spinal dorsal horn circuits likely caused by a loss of local inhibition. However, the molecular mechanisms that le

Chronic psychosocial stress is a significant risk factor for the development of stress-associated psychiatric disorders, including major depressive disorder, which causes profound debilitation and has increasing worldwide prevalence. Pre-clinical and clinical studies have linked peripheral immune system alterations to stress-related disorders, such as elevated levels of proinflammatory immune cells and cytokines in circulation. Endothelial cells are critical components of the blood-brain barrier (BBB), as they interface directly with immune cells and their released factors, which can enter the