Topic: TRPV1 receptors

Temporal lobe epilepsy (TLE) is one of the most prevalent neurological disorders, affecting 1-3% people worldwide. As this type of epilepsy is often refractory to anticonvulsant drugs, it is crucial to advance the understanding of the mechanisms that underlie its pathophysiology. The endocannabinoid system (ECS) protects nerve cells through the cannabinoid CB1 receptor regulation of the glutamatergic neuronal excitability. As TLE patients frequently show changes in the ECS, in this study we analyze the impact of the status epilepticus in the hippocampus four weeks after administraton of the pr

Capsaicin (CAP), has undergone extensive research in recent years due to its potential for pain relief, attributed to triggering the activation of TRPV1 receptors, known to be sensitized in painful conditions. This study aims to investigate CAP role in pain therapy within hTRPV1-expressing cell systems, namely ND7/23-hTRPV1 and CHO-hTRPV1. ND7/23 transfection with hTRPV1 was conducted to generate a neuronal model mirroring dorsal root ganglion neurons physiology, involved in pain transmission. To ascertain its specificity to CAP, calcium imaging (CI) was performed. Additionally, automated patc