Topic: two-photon functional imaging

The perception of an ambiguous stimulus rely on the activation of multiple cortical areas, operating a sensorimotor transformation along the cortical hierarchy. Furthermore, choice related information is found as upstream as the primary sensory areas, suggesting bi-directional communication at all stages of the cortical hierarchy. How do sensory and choice related activities flow and organize across multiple brain areas? Here, we designed a two-alternative forced-choice task (2AFC) in which mice compared stimulation frequencies applied to two adjacent vibrissae. Using two-photon functional ima

When larval zebrafish experience whole-field visual motion, as in the random-dot task, they swim in the direction of motion - an innate behavior enabling animals to maintain position in moving water. This behavior is well-explained by the same drift-diffusion algorithm that captures human and primate behavior in analogous random-dot paradigms. We previously proposed a hypothetical circuit model that implements this algorithm via a recurrent integrator circuit in the zebrafish hindbrain that accumulates noisy visual evidence and excites downstream motor circuits after overcoming competitive inh