Topic: unconventional protein secretion

Intracellular membrane protein trafficking is crucial for both normal cellular physiology and cell-cell communication. It is now established that intracellular trafficking not only uses the conventional secretory pathway but also an alternative secretion pathway able to bypass the need for passage through the Golgi apparatus, which is collectively termed unconventional protein secretion. One of the major actors of this pathway is the vesicular SNARE VAMP7, which is involved in the secretion of extracellular vesicles of late endosomal origin called exosomes. It was recently shown that exosomes