Topic: vascular dysfunction

Dementia is a term for several diseases that affect memory, thinking, and daily activity performance. The most prevalent form of dementia is Alzheimer’s disease (AD), which explains 60-70% of dementia cases (World Health Organization [WHO], 2023). AD is a neurodegenerative disorder characterized by brain atrophy, gliosis, Abeta and tau proteinopathies, and vascular dysfunction. Previously, our group has described that a non-productive angiogenesis (NPA) phenomenon occurs around Abeta plaques, giving rise to disassembled, low-perfused vascular structures, which we have called vascular scars (Va