Topic: vGENUS

Visual gamma entrainment using sensory stimuli (vGENUS) is a promising non-invasive therapeutic approach for Alzheimer's disease (AD), showing efficacy in improving memory function and physiological biomarkers levels in mice and, in perspective, also human patients. However, its mechanisms of action remain poorly understood. Explanations in terms of boosted neurogenesis or glymphatic clearance have been advanced. Here we probe the alternative hypothesis that this non-invasive and non-pharmacological stimulation acts by increasing the fluidity of brain dynamics. Our hypothesis expands upon prev

Alzheimer’s disease (AD) is a neurodegenerative disease and the world leading cause of dementia, yet still no effective treatments are available. Recently, a non-invasive therapy based on 40 Hz gamma stimulation using sensory stimuli (GENUS) showed beneficial effects on memory performances in several AD mouse models and mild probable AD patients. However, mechanisms underlying these positive effects, such as amyloid plaque clearance, microglial activation or gamma rhythm restauration, are still matter of intense debate. Here, we test the alternative hypothesis that GENUS might rescue memory de