Topic: VIP-INs

Several populations of GABAergic interneurons (INs) are strongly regulated by neuromodulatory input during distinct behavioral states, and thus may be key contributors to flexible cortical function. One prominent model suggests vasoactive intestinal peptide-expressing INs (VIP-INs) activate upon arousal, suppress the activity of downstream INs (SST-INs), and consequently disinhibit pyramidal neurons (PNs). This VIP-SST-PN disinhibitory circuit is hypothesized to be a general cortical circuit motif allowing behavioral state signals to modulate sensory processing. Cortical VIP-INs, however, have

GABAergic interneurons (INs) highly impact cortical development. For instance, early postnatal dysregulation of vasoactive intestinal polypeptide (VIP)- expressing GABAergic INs has been shown to impair sensory processing and learning, emerging from adolescence on. Thus, investigating the functional maturation and network integration of VIP-INs is important for understanding brain development. Here, we studied developmental changes in passive and active membrane parameters of VIP-INs and their network integration into the developing neocortex with an emphasised focus on the maturation of their