Topic: wasteosomes

Wasteosomes (or corpora amylacea) appear in the human brain during aging and in some neurodegenerative conditions. They entrap waste substances originated from different cell types and can be released from the brain to the cerebrospinal fluid (CSF). Their presence in the CSF was described using electron microscopy, PAS staining and immunofluorescence with natural IgMs and anti-glycogen synthase (GS) antibodies. However, the methods employed involved the use of a large sample volume for each staining, which hindered wasteosomes characterization. In the present work, we examined a new method to

Wasteosomes (or corpora amylacea) appear in the human brain with advancing age and in some neurodegenerative diseases. They have been proposed to accumulate waste substances and to contribute to a brain-cleaning mechanism. In this context, wasteosomes may have the potential to entrap some of the proteins that misfold, aggregate and accumulate in neurodegenerative diseases. In this work, we aim to characterize wasteosomes in the three primary frontotemporal lobar degeneration (FTLD) proteinopathies: FTLD with tau (FTLD-tau), FTLD with TAR DNA-binding protein 43 (FTLD-TDP) and FTLD with Fused in