Topic: Whole-brain functional imaging

To track and control self-location, animals integrate their movements through space. Representations of self-location are observed in the mammalian hippocampal formation (1,2), but it is unknown if positional representations exist in more ancient brain regions, how they arise from integrated self-motion, and by what pathways they control locomotion. Here, in a head-fixed, fictive-swimming, virtual-reality preparation (3), we exposed larval zebrafish to a variety of involuntary displacements. They tracked these displacements and, many seconds later, moved toward their earlier location through c

The brain allows animals to make dynamic behavioral changes in response to changing internal or external demands. Determining precisely how this happens is challenging because existing methods for recording neural activity perturb natural behavior. With the recent advent of tracking microscopy, the larval zebrafish is an ideal vertebrate model for recording brain-wide cellular-resolution neural activity in freely behaving animals during natural behavior. However, current imaging methods such as structured illumination or light field microscopy, compatible with tracking microscopy, rely on high