Topic: wide-field calcium imaging

Small vessel disease is characterized by stochastic occlusions of small vessels in the brain microvasculature. This results in impaired blood flow, increased blood-brain barrier permeability and neuronal cell death. While small vessel disease is the leading cause of vascular dementia, the underlying mechanisms remain elusive, limiting treatment options. Visual stimulation at specific frequencies can enhance neuronal activity, leading to remodelling of the cerebrovascular architecture. Specifically, evoked gamma oscillations through stimulation at 40Hz has been shown to rescue motor and cogniti

Beta-adrenergic receptors (B-ARs) regulate hippocampal synaptic plasticity associated with spatial memory in rodents (doi: 10.1002/hipo.22168). Synaptic plasticity supports the refinement and stabilisation of neuronal ensembles. This study aimed to examine the effect of noradrenergic regulation of dorsal hippocampal neuronal activity during spatial learning. For this, we used wide-field calcium imaging as a method to study B-AR modulation of the activity of visualised hippocampal CA1 neurons during item-place learning that is known to trigger hippocampal long-term depression (LTD) (doi: 10.109

The mammalian cerebral cortex presents a modular organization, enabling the segregation of specialized functions and the generation of complex cognitive states. In the mouse, the anatomical and functional correlates of this network topology arise during the perinatal period. Especially after birth, spontaneous neural activity and sensory inputs trigger complex spatio-temporal firing patterns, which affect the cytoarchitecture and connectivity of cortical regions. Thus, understanding how local activity patterns emerge, interact and impinge on cortex-wide dynamics is essential to elucidate the p

In the cerebral cortex, activity dynamics measured at a mesoscopic (0.1 to 1 mm) scale are characterized by both spontaneous and task-related dynamical waves of synchronized neuronal activity ranging from spreading stationary depolarizations (blobs) to traveling waves that can follow complex trajectories throughout the cortical network. These waves are thought to participate in information propagation and processing, but remain poorly understood. To test whether cortical waves can be actively generated and their trajectory controlled, we have implemented a goal-directed task for head-fixed mic