Topic: WZB117

Due to its extremely finite energy reservoir, the brain is heavily reliant on blood-borne metabolites and their delivery through the blood-brain barrier to meet its regional and transient bursts of energetic needs. Despite this reliance, few studies investigating the controversial question of neuronal lactate use measure the contribution of peripheral metabolites. In this study, we investigated the impact of peripheral transporter inhibition on cortical extracellular metabolite fluctuations. The glucose (GLUT1; WZB117) and monocarboxylate (MCT1; AZD3965) transporter inhibitor, were administere

N-Methyl-D-aspartate receptors (NMDAR), a class of ionotropic glutamate receptors, play a critical role in synaptic transmission and plasticity in the central nervous system. A unique subtype of these receptors, GluN1/3A, predominantly expressed during early brain development, has been recently proposed as an excitatory glycine receptor. Our investigation aims to deliver a comprehensive characterization of the mechanism of action of recently reported selective GluN3A inhibitors by using a stable cell line expressing recombinant GluN1/3A receptors. Furthermore, we are describing an assay for ev