Topic: yohimbine

The noradrenergic (NA) system plays a critical role in memory consolidation, including declarative memory. Recognition memory, an important aspect of declarative memory, involves the ability to acquire and recall information to identify familiar stimulus. Novel Object Recognition (NOR) is a widely used task to assess this type of memory in rodents. This test is based on the innate preference for novelty and the ability to discriminate novel and familiar objects. Post-training yohimbine administration, an a2-adrenoceptor antagonist, enhances object location memory in mice, suggesting that incre

In humans, loss aversion is sensitive to stress, and patients with neurological or psychiatric illnesses are particularly vulnerable to the detrimental effects of stress that lead to suboptimal life-altering choices. The basolateral amygdala (BLA) and nucleus accumbens (NAc) are stress sensitive brain areas that alter extracellular levels of norepinephrine (NE) and dopamine (DA), respectively. However, the dynamics of neurotransmitter release in these brain regions during stress has not been systematically explored. We used pharmacology and fiber photometric analysis to elucidate the impact of

Ellagic acid (EA) is a polyphenol that contributes to the nutraceutical properties of pomegranate. In the brain it was reported to control noradrenaline release. Recently, we demonstrated that EA binds α2 receptors (α2R), mimicking the full-agonist clonidine. The study was extended to Urolithins (URO) A, B and C which represent the main metabolites of EA in mammals, following a chronic (14 days) administration of an EA micro-formulation (EAm).“In vitro” studies were carried out on cortical and hippocampal synaptosomes isolated from control mice acutely exposed to the UROs, clonidine and yohimb