Clinical Neurophysiology ePosters

Developing a technology able to measure in-vivo and non-invasively the electrical activity of the human spinal cord would fulfill an important and still unmet need in both basic and clinical research. In this work, we describe a novel recording and analysis pipeline to obtain non-invasive, high-resolution images of…

Interictal epileptiform discharges (IEDs) are brief, sporadic, pathologic electrical bursts in the brains of patients with epilepsy. IEDs represent an important disease biomarker for tracking seizure risk and they also convey direct pathophysiological impacts including on cognitive function. While most work in human…

Counterfactual information, or the mental representation of alternative outcomes, plays a critical role in value-based decision-making by allowing individuals to evaluate both chosen and unchosen options. Aberrant counterfactual processing is linked to psychiatric disorders like major depressive disorder (MDD). While…

Burst-suppression (BS) is a highly structured electroencephalogram (EEG) pattern characterized by alternating periods of high-voltage activity (bursts) and low or flatline activity (suppression). In non-anesthetized adults, BS indicates severe brain pathology, e.g. due to oxygen and glucose deprivation [1]. There are…

The human language system comprises a series of processing stages across multiple brain regions typically lateralized to the left cerebral hemisphere. In the event of stroke or other injury to these systems, neural circuits reorganize in an attempt to restore lost function. However, the neural processes and learned…

Brain activity lies on a very complex network. This complexity is multiple but a prominent one is the non-linear and multi-factorial interaction between its nodes. In the specific case of Parkinson's disease (PD), the brain loses dopaminergic neurons in the substantia nigra compacta (SNc). Highly involved in the basal…

Humans keep track of temporal intervals for different goals, from explicitly reporting perceived magnitudes to implicitly orienting attention in time. Whether overlapping or segregated timing mechanisms subserve these timing processes is a key neuroscientific question. Neuroimaging studies revealed goal-dependent…

This study delves into an examination of heart rhythm patterns among patients afflicted with disorders of consciousness. The research primarily focuses on the analysis of polysomnographic recordings in the time domain while also exploring methodologies for evaluating peripheral signals. An algorithm aimed at detecting…

Our goal is to extend the open thermodynamic model of cortical neurodynamic Freeman hypothesis using the theoretical Carnot and then Rankine Cycles to define biomarkers for mean field energy versus entropy change and relevancy to temperature. We are using the Rankine cycle to incorporate criticality which is at null…

Speech impairment is reported among 70% of the Parkinson’s disease (PD) population, deeply impacting individual quality of life and social costs. Because of the lack of efficacy of pharmacological and DBS treatments, we developed an experimental protocol based on the Lee Silverman Voice Therapy (LSVT) and transcranial…

The default mode network`s (DMN) can be investigated using default EEG reactivity (DER).The default oscillatory macrostate (DEM) is exemplified by the macrostate showing thehighest decrease in occurrence probability during intermittent photic stimulation (IPS).This study aimed to investigate DER, in the deeply sedated…

Amyloid-beta (Aβ)-induced changes in neuronal activity could yield valuable early markers of Alzheimer’s disease (AD). The neurophysiological manifestations associated with early Aβ-pathology in humans are however not well defined. This study investigated the relationship between Aβ-pathology and neurophysiological…

Frontal alpha asymmetry in Major Depressive Disorder has been widely examined in EEG research. Recently, the EEG has also been suggested as a potential diagnostic biomarker for Seasonal Affective Disorder (SAD), a recurrent Major Depressive Disorder with a seasonal pattern. However, thus far no studies have been…

Spinal neuromodulation via epidural electrical stimulation is a promising therapy for motor function restoration of patients with spinal cord injury. By applying specific sequences of electrical stimulation to the spinal cord through the electrode array, the patient can achieve multiple movements. However, one of main…

Human invasive EEG recordings are used to guide clinical decision-making for epilepsy patients and offer an opportunity to better understand underlying neurophysiology. However, the relationship between macroscale electrophysiological recordings and underlying neural networks mechanisms remain unclear. Lundstrom et al…

INTRODUCTION Graph theory is a state of the art approach to assess functional connectivity (FC) disruption in neurological disorders. However, this methodology does not allow distinction between positive and negative FC correlations; negative correlations, or anticorrelations, are usually either discardes or taken as…

The domain of computational neuroscience is one that is awash with data; be it from simulations or experiments, we try to extract patterns and make sense of them. However, two trends have emerged over the past decade. For one, datasets are rapidly increasing in scale, breadth and depth, as more research demands higher…

Transcranial Magnetic Stimulation (TMS) offers a non-invasive clinical treatment for intractable neuropsychiatric disorders, including Major Depressive Disorder (MDD). Repetitive TMS (rTMS) involves administering a series of patterned magnetic pulses through the skull to modulate cortical brain activity and induce…

Mild traumatic brain injury (mTBI), also referred to as concussion, is a common yet incompletely understood condition of the central nervous system. While traditionally considered to be limited in scope and self-resolving, recent studies point to a much more insidious nature of the injury that can continue to evolve…

Spinal cord stimulation is a promising therapy for the recovery after spinal cord injury and control of movement. However, the complex interaction between electrodes and neural reaction impedes more effective neuromodulation. Empirical knowledge and manual adjustment are playing dominant role for the tuning of…