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<B DATA-OLK-COPY-SOURCE="MESSAGEBODY">DISRUPTION OF PERINEURONAL NETS AND DIFFUSE EXTRACELLULAR MATRIX IN VENTRAL-INTERMEDIATE HIPPOCAMPUS DOES NOT AFFECT RAPID PLACE LEARNING, NOVEL OBJECT RECOGNITION MEMORY OR LOCOMOTOR ACTIVITY </B>
Jacob Jutyand 8 co-authors
University of Nottingham
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS04-08PM-580
Presentation
Date TBA
Board: PS04-08PM-580
Event Information
Poster Board
PS04-08PM-580
Poster
View posterAbstract
Extracellular matrix (ECM) provides structural and biochemical support to cells. Perineuronal nets (PNNs), a condensed form of ECM, surround parvalbumin (PV)-expressing interneurons in the hippocampus and have been suggested to be important for maintaining balanced GABAergic inhibition in adulthood. Although PNN/ECM disruption has been implicated in brain disorders, including schizophrenia, the cognitive and behavioural consequences of hippocampal PNN loss remain largely unstudied. Here, we examined the impact of ventral/intermediate hippocampal PNN/ECM attenuation by chondroitinase-ABC (chABC) on behavioural measures that require the ventral/intermediate hippocampus and local GABAergic inhibition.
Male young adult (310-370g at the time of surgery) Lister hooded rats were implanted with indwelling guide cannulae targeting the ventral hippocampus. We then examined behavioural functions requiring ventral hippocampal GABAergic inhibition, namely watermaze rapid place learning (delayed match-to-place; DMP), novel object recognition (NOR) memory and locomotor activity (McGarrity et al., 2017, CerebCortex; Taylor et al., 2025, JNeurosci) both before, and during the 5 days after, infusion of either chABC or penicillinase (control). WFA histochemistry showed that chABC infusion degraded chondroitin-sulfate proteoglycans (CSPGs), a main component of PNNs and diffuse ECM, throughout ventral to intermediate hippocampus. However, none of the behavioural measures were affected by chABC or penicillinase infusion. Quantification of the impact of chABC on PV-expressing interneuron density is ongoing. Overall, our findings suggest that PNNs and diffuse ECM integrity in the ventral to intermediate hippocampus are not required for behavioural functions that depend on local GABAergic inhibition.
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