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ePoster
INTRACEREBROVENTRICULAR ADMINISTRATION OF SERUM-DERIVED EXOSOMES MEDIATED DEPRESSION-LIKE BEHAVIORS IN MICE.
Jorge Manuel Vasquez Perezand 8 co-authors
Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS04-08PM-056
Presentation
Date TBA
Board: PS04-08PM-056
Event Information
Poster Board
PS04-08PM-056
Poster
View posterAbstract
Currently, exosomes—a type of extracellular vesicle (EV)—are considered an important mechanism of cellular communication and regulation in the central nervous system (CNS), both in homeostatic and pathological processes. However, research on the influence of peripheral EVs (blood) on the CNS in psychiatric disorders such as depression is still limited. Here, we describe an interaction between blood serum exosomes from patients diagnosed with depression, administered intracerebrally, and the generation of depressive-like behaviors. We isolated, quantified, and characterized the exosomes using size exclusion chromatography (SEC), transmission electron microscopy (TEM), CD63-ELISA, Bradford assay, positron emission tomography (PET) to evaluate metabolic changes in the CNS caused by the exosomes, and antibody arrays to identify their protein content. Exosomes from patients with depression generated depressive-like behaviors in Balb/C mice. Bioinformatic analyses of protein expression and interaction showed sets of proteins associated with pathways such as cytokine-cytokine receptor interaction, JAK-STAT signaling, Rap1, Ras, TNF, and chemokine signaling. Additionally, histological analyses suggest that exosomes may interact with microglia, thereby modulating the proliferation and differentiation of newly generated neurons in specific regions of the hippocampus. These results suggest that peripheral exosomes contain a specific proteomic profile that can modulate depressive-like behaviors in rodents. These EV’s may become a potential biomarker for psychiatric disorders such as depression in the future.
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