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LRRTM4 CONTROLS CELL MIGRATION THROUGH GLYPICAN RECEPTORS
Peregrina Cabredoand 7 co-authors
University of Barcelona
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS03-08AM-425
Presentation
Date TBA
Board: PS03-08AM-425
Event Information
Poster Board
PS03-08AM-425
Poster
View posterAbstract
Leucine-rich-repeat-transmembrane neuronal proteins (LRRTMs) play a major role in neuronal connectivity and synapse formation, but their function during development and roles in cell migration have not been described. Here, we identify LRRTM4 as a major coordinator of cell migration in the developing cortex and several cancer cells. We show that these functions depend on interactions with the core domain of glypicans, which, in the midgestational murine cortex, are presented by radial glia cells. Using structural predictions and site-directed mutagenesis to abolish the LRRTM4-glypican interaction, we demonstrate that glypican-bound LRRTM4 mediates contact-repulsion in both migrating neurons and diverse cancer cells. Our results demonstrate that LRRTMs are used to respond to glypicans by migrating cells in distinct biological contexts.
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