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ROLE OF THE HYPOTHALAMIC RXR RECEPTORS IN METABOLIC HOMEOSTASIS
Nicolás Fernández Malvidoand 4 co-authors
CiMUS (Universidade de Santiago de Compostela)
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS01-07AM-670
Presentation
Date TBA
Board: PS01-07AM-670
Event Information
Poster Board
PS01-07AM-670
Poster
View posterAbstract
Hypothalamus is a key element in the regulation of energy balance and calory intake. In this region, SF1 neurons have a pivotal role in the monitoring and regulation of metabolic homeostasis. This study aims to find out if retinoid X receptors (RXR), involved in many signaling processes, are part of regulating mechanisms of these neurons and if their role is linked to energy balance and body weight. We used FISH techniques (RNAscope®) in Sf1-tdTomato reporter mice to check for RXR expression in SF1 neurons. We then created a KO mouse strain for all three isoforms of RXR sepcifically in SF1 neurons, using Cre-lox technology. We ran a full metabolic phenotyping of KO mice, using their littermates as negative control. We found out that deletion of RXR in SF1 neurons causes a body weight increase. Therefore, it can be concluded that RXR receptors are expressed in the hypothalamus and their presence in SF1 neurons is needed for a correct regulation of energy balance.
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