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SPATIAL AND TEMPORAL EXPLORATION OF THE EVOLUTION OF BRAIN CHANGES IN SEPSIS-INDUCED COGNITIVE DYSFUNCTION AND NEURODEGENERATION – SEED
Emily Iliana Michailand 5 co-authors
University Medical Center Groningen
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS03-08AM-143
Presentation
Date TBA
Board: PS03-08AM-143
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Poster Board
PS03-08AM-143
Poster
View posterAbstract
Delirium, a severe neuropsychiatric syndrome, commonly manifests among geriatric and frail individuals as acute cognitive impairment. Despite its temporary nature, it is associated with severe long term neurodegenerative burden. With the SEED project, we aim to explore the largely unknown pathophysiology of sepsis-associated delirium, and its long-term consequences. We propose that molecular events occurring in the brain during sepsis plant a seed for more rapid cognitive decline and earlier onset of dementia. Using the cecal slurry mouse model for sepsis, we will combine spatial transcriptomics and blood proteomics in order to characterize the spatiotemporal trajectory of molecular changes in murine brains following systemic inflammation, integrating these with the evolution of acute and long-term cognitive changes. The wave of inflammatory and metabolic changes radiating from the brain vasculature to microglia and astrocytes, to white matter tracts and precipitating molecular changes in neurons will provide a rich single-cell dataset currently unavailable for the brain during sepsis. Using blood samples from unique cohorts of sepsis patients we will translate, in humans, key molecular pathways we have identified in murine brains. Our study will address a major knowledge gap in sepsis-related acute cognitive decline and ultimately, broaden understanding on the pathophysiology of delirium, and its molecular association to dementia.
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