Gastroenterology ePosters

Experimental autoimmune encephalomyelitis (EAE) is a laboratory model for multiple sclerosis (MS), an autoimmune disease characterized by chronic inflammation in the CNS, associated with demyelination and neurological disorders. Dysbiosis of the gut microbiota is a risk factor for MS. Probiotic strains can modulate…

Acute stress exposures are the building blocks of chronic stress. Unravelling the mechanisms underpinning the whole-body response to acute stress is critical to understand this neglected aspect of health and disease. A single acute stress exposure rapidly modulates gut-brain axis signalling including intestinal…

Parkinson’s disease (PD) results in midbrain dopaminergic neuron degeneration and neuronal accumulation of alpha-synuclein (a-syn). The ‘brain-first vs body-first’ hypothesis of PD proposes that a-syn pathology begins in the brain then spreads to the gut, or conversely begins in the gut then spreads to the brain, via…