Senior Research Associate, Genetic Perturbation Screening (Fixed-Term Contract)

Support arrayed and pooled genetic perturbation screens in disease-relevant human pluripotent stem cell (hPSC)-derived microglia as part of the Molecular Engineering team in Arc's Genome Engineering Technology Center, for the Institute's Alzheimer's Disease Initiative. The role runs stem cell culture and microglia differentiation, medium- to high-throughput lentiviral transduction of arrayed genetic perturbations into engineered cell lines, and functional characterisation of perturbed cells by flow cytometry, imaging, immunostaining and molecular biology, with records kept in an ELN and LIMS and protocol troubleshooting and improvement.

This is a 12-month fixed-term position based on site in Palo Alto five days a week; it is not eligible for visa sponsorship. Base salary range: USD 84,250-106,000.

BS with 4+ years or MS with 2+ years of relevant experience; proficient stem and progenitor cell culture and characterisation; plate-based or automation-compatible screening workflows; multi-colour flow cytometry, immunostaining and FlowJo analysis; LIMS experience (ideally Benchling); strong organisation and communication. Preferred: differentiating hPSCs into neural or immune lineages (especially microglia), automation, CRISPR-Cas9 or other genome editing, molecular cloning, virus production and cell line engineering.