7 results
Lead chemical biology and drug design connecting multiomic discovery to target identification. The team develops chemical probes and emerging modalities, including targeted degradation and molecular glues, and integrates experimental chemistry with computational and generative design while managing scientific programmes and external partners.
Drive peptide drug programmes through rapid design, synthesis and testing cycles linked to machine-learning models. Work includes automated peptide synthesis, structure–activity analysis, assay interpretation, ADMET optimisation and cross-functional collaboration, with mentoring and management of external research partners.
Develop safe, scalable synthetic routes for small-molecule intermediates and drug substances. Laboratory work covers route scouting, optimisation, impurity identification and analytical characterisation, followed by technology transfer to manufacturing partners and collaboration with formulation and quality specialists.
Lead peptide drug discovery from hit optimisation to development candidates. The role combines peptide chemistry, machine-learning-guided design, cross-functional programme leadership and mentoring, working with DMPK, toxicology, CMC and clinical teams to advance oral peptide therapeutics.
Design, synthesise and purify compounds for potential clinical drug development in Amgen’s medicinal-chemistry group. The role includes difficult organic synthesis, route development, structure–activity relationships and structural analysis by NMR and mass spectrometry. Work may involve the Induced Proximity Platform and PROTAC approaches. This is an…
Lead computational chemistry contributions to drug programmes from early discovery towards candidate selection. Combine structure-based and ligand-based design with AI predictions, work closely with machine-learning scientists and experimental teams, and guide external research activities. The role includes scientific leadership and mentoring. The…
Build machine-learning and computational-chemistry software supporting molecular property prediction, virtual screening, reaction optimisation and drug design. Work spans production pipelines and methods such as molecular dynamics, docking, free-energy calculations and retrosynthesis, in collaboration with discovery scientists. The advertised salary range…
End of results.