Microbial Ecology ePosters

The role of dysregulated gut microbiota (GM) is widely recognized as relevant to the pathogenesis of Parkinson's disease (PD), particularly in case of non-motor symptoms such as depression and anhedonia. Most transgenic mouse models of PD, however, don’t exhibit clinically relevant dysbiosis. Here, for the first time,…

Alzheimer’s disease (AD) is the most common form of dementia. Its strongest genetic risk factor is the e4 allele of the apolipoprotein E (APOE), and risk scales with APOE-e4 load (e4/e4 > e4/e3 > e3/e3). APOE-e4 has been linked to distinct gut microbiome composition in murine models, but genotype effects on the human…

Parkinson's disease (PD) is characterized by the degeneration of dopaminergic neurons in the substantia nigra, and it has been reported that α-synuclein accumulates in the gut and then affects the brain along the gut-brain axis. In this study, we used Enterococcus faecium (EF), which was probiotics, that confer health…

Experimental autoimmune encephalomyelitis (EAE) is a laboratory model for multiple sclerosis (MS), an autoimmune disease characterized by chronic inflammation in the CNS, associated with demyelination and neurological disorders. Dysbiosis of the gut microbiota is a risk factor for MS. Probiotic strains can modulate…

Parkinson’s disease (PD) results in midbrain dopaminergic neuron degeneration and neuronal accumulation of alpha-synuclein (a-syn). The ‘brain-first vs body-first’ hypothesis of PD proposes that a-syn pathology begins in the brain then spreads to the gut, or conversely begins in the gut then spreads to the brain, via…