Molecular Biology podcasts

Sarah Crespi and Tim Appenzeller discuss a resurfaced Rosalind Franklin X-ray photograph and its implications for the history of DNA structure. Elah Feder then speaks with Andreas Nieder about experiments comparing the speed of decisions in crows and primates, considering neural mechanisms and evolutionary advantages. Phil Levin and David Hassler discuss collaboration between ecological research and poetry, with a reading by Lara Volski.

Hosted by Sarah Crespi

Torrey Rhyne-Carrigg discusses DNA initiators and how models help investigate the molecular processes controlling gene activity. The conversation also follows her research training through the Graduate Research Fellowship Program, connecting fundamental biology with the development of scientific methods and a research career.

Saloni Dattani and Jacob Trefethen discuss siRNA medicines that suppress production of harmful proteins without changing DNA. They examine the long path from discovery to treatment, why existing drugs concentrate on liver diseases, programmable and long-lasting effects, and prospects and limitations for treating infection, cardiovascular disease, rare disorders and cancer.

Hosted by Saloni Dattani, Jacob Trefethen

Francesca and Ilaria discuss taste-receptor research, mitochondrial biology and a reported ALS case study involving an antisense oligonucleotide treatment. Giuliana Galati interviews University of Padua physicist Francesco Recchia about nuclear phenomenology. The episode links these discussions to the underlying research papers and distinguishes a clinical case report from established treatment evidence.

Hosted by Francesca Cecilia Lauta, Ilaria Zanardi

Vincent Racaniello, Alan Dove and Brianne Barker discuss a newly identified mechanism for RNA-guided DNA recognition and genetic control that may predate CRISPR pathways. They also examine research proposing that features of Alzheimer’s disease neuropathology could have originated as a host response to infection in the brain, including evidence concerning phosphorylated tau and herpesvirus activity. The episode connects ancient molecular recognition mechanisms with questions about antiviral defence.

Hosted by Vincent Racaniello, Alan Dove

Chris Smith presents research on individual differences in fruit flies, colour-linked pupil responses in synaesthesia, and how mating patterns broaden cognitive variation in chickadees. The episode also examines which species succeed in cities and how DNA organisation changes in cancer. The publisher provides a full episode player and individual interview transcripts.

Hosted by Chris Smith

Vincent Racaniello speaks with Roberto Cattaneo and Kalpana Yadav at the 2026 American Society for Virology meeting about measles persistence in the brain. They discuss selection for highly fusogenic viral variants when usual measles receptors are absent, neuron-to-neuron spread, and the development of subacute sclerosing panencephalitis, a rare, fatal delayed complication of measles infection.

Hosted by Vincent Racaniello

Paul Bieniasz joins Vincent Racaniello, Alan Dove and Kathy Spindler to discuss his laboratory’s research on coronavirus genetic variation. The conversation examines how the NSP15 nuclease cuts viral RNA into short pieces that can be reinserted elsewhere, producing insertion mutations and new furin-cleavage sites at the spike S1/S2 boundary. The episode links the underlying preprint and includes listener correspondence and weekly selections.

Hosted by Vincent Racaniello, Alan Dove

An audio feature examining research on DNA damage, repair and ageing. The episode explores evidence that inadequate repair contributes to age-related biological changes, and scientific efforts to test whether improving repair can extend healthy life. Nature published this episode on 2 September 2026.

Scientific American's Science Quickly examines new recommendations highlighting sperm DNA damage as an underrecognized contributor to recurrent miscarriage. Rachel Feltman and Sarah Elizabeth Richards discuss why conventional sperm tests can miss pregnancy-relevant problems and how broader assessment could change fertility care.

Gaute Einevoll talks with Tatjana Tchumatchenko about a mechanistic mathematical model of how neurons minimize energy use by deciding whether ion-channel proteins are produced locally in dendrites or in the soma. The model’s predictions agree with experimental findings.

Nature staff discuss evidence from whales and mole rats suggesting that DNA repair may contribute to longevity, and how COVID-19 can reactivate dormant viruses.

Bonnie Bassler explains how bacteria detect signals from their surroundings and coordinate behaviour through quorum sensing. Chemical communication allows microbes to sense nearby populations and undertake collective activities that individual cells could not accomplish alone. The discussion examines bacterial information processing and the consequences of these coordinated behaviours, including within the human body.

Hosted by Sean Carroll

Oded Rechavi discusses scientific peer review, grant assessment and the possibilities and limitations of AI-assisted research validation. Drawing on his work with C. elegans, he explains research into how experiences can influence descendants through RNA-mediated inheritance. The conversation also covers ancient DNA and the Dead Sea Scrolls, automation in biology and the distinction between supporting researchers and replacing scientific judgment.

Jeff Coller explains how messenger RNA carries information from DNA to the machinery that produces proteins and how researchers are learning to use it therapeutically. The conversation covers vaccination, tailored treatments and approaches connected with gene editing, placing these developments in the broader biology of RNA and its possible role in the origins of life.

Hosted by Sean Carroll

Jennifer Doudna discusses how CRISPR changed gene editing and what might come next. The conversation examines emerging applications, technical limitations and the ethical choices involved in altering genetic material, including how scientific progress can be paired with responsible use.

Hosted by Janna Levin

Mariana Kneppers, Mason Wakley and Neil Withers discuss two questions about genetic information. They examine AlphaGenome, a machine learning model designed to predict molecular effects of DNA variants across long sequences, and consider its potential use in genetics research. The episode then turns to the RNA world hypothesis: the proposal that RNA-based systems preceded DNA genomes and cells during the early history of life. The discussion links contemporary tools for studying the genome with chemical questions about life's beginnings.

Hosted by Mariana Kneppers

Dan Nicholson re-examines Erwin Schrödinger's What Is Life? and its influence on molecular biology and the metaphor of organisms as machines. The conversation considers deterministic physics, genetic coding, development and negentropy, then asks how that intellectual history continues to shape explanations in neuroscience and artificial intelligence.

Hosted by Paul Middlebrooks

Nikolay Kukushkin connects research on cellular memory with a broader account of mind and meaning. Drawing on molecular biology, evolution and his book One Hand Clapping, he examines relationships across scales and the proposal that minds are continuous with the processes and environments from which they emerge.

Hosted by Paul Middlebrooks

Sam Gershman discusses molecular accounts of memory and how they relate to the dominant view of storage through changes in synapses.