Numerical Analysis ePosters

Understanding the mechanisms regulating Ca2+ concentrations in the presynapse is crucial for synaptic function. The endoplasmic reticulum (ER) acts as a finite calcium store and can modulate calcium signals involved in presynaptic neurotransmitter release. While computational studies have shed light on the…

Networks composed of Non-Negative Matrix Factorization (NNMF) [1] modules can serve as abstractions of real neural networks. In particular, NNMF networks can be extended easily to perform computations based on stochastic spikes [2,3]. However, due to training via Autograd approaches following exact gradients to train…

In neuroscience, ordinary differential equations (ODEs) are widely used to simulate the dynamics of neural systems, but identifying parameters that explain experimental measurements is challenging. In particular, while these models are differentiable and would allow for gradient-based parameter optimization, the…

A model for NMDA-receptor-mediated synaptic currents generating persistent activity proposed by Wang and Brunel [1–3] has been widely adopted in computational neuroscience, both for spiking-neuron and mean-field models [2, 4]. The model describes NMDA synaptic dynamics by a phenomenological two-dimensional nonlinear…