Optics ePosters

The onset of a stimulus, whether sensory or non-sensory, quenches trial-to-trial neural variability. The universality of this phenomenon across brain areas and species implies that it is a fundamental strategy employed by the brain to boost the fidelity of stimulus representation. Multiple network models have…

We introduce OpenEyeSim 2.1, an extension of the OpenEyeSim platform that includes simulation of accommodation control and chromatic aberrations. It is suitable for developing models of the joint learning of visual representations, eye movements, and accommodation control in the perception-action cycle. The simulated…

Much of our current understanding of brain-based visual processing is derived from studies involving immobilised animals. However, in reallife scenarios, visual perception is intrinsically linked with the movements of the eyes, head, and body. To gain amore comprehensive understanding of visual processing under these…

Glioblastomas (GB) are the most malignant primary brain tumors with median survival of about 17 month despite extensive treatment. Molecular heterogeneity and the tumor microenvironment contribute to the challenges in treating GBs. Glioma-associated microglia and macrophages, comprising 30-50% of non-neoplastic cells…

Microglia-synapse interactions have been examined in a variety of contexts, in vitro and in vivo, which revealed an important role for microglia in synaptic pruning and loss. Nevertheless, it remains to be determined whether and how microglia are involved in the process of synapse formation under physiologic…

To study the neural correlates of naturalistic behaviors, we seek to record neural activity in unrestrained animals. Due to behavior-induced motion artifacts, such recordings are particularly challenging for two-photon fluorescence microscopy. Studying multi-neuronal activity in the central nervous system in moving…

Studying chemosensory processing desires precise chemical cue presentation, behavioral response monitoring, and large-scale neuronal activity recording. Larval zebrafish are especially attractive vertebrates for such study. Behavioral assays and imaging systems that can achieve the necessary spatial precision for…

Miniature head-mounted microscopes have enabled in vivo optical measurements of neural activity in freely moving animals, allowing neuroscientists to study the neural basis of behaviors that are difficult to recapitulate in head-fixed preparations like social interaction and navigation. Existing head-mounted…

Due to the size and opacity of vertebrate brains, it has until now been impossible to simultaneously image neuronal circuits at cellular resolution across the entire adult brain. Thus, any recording is an implicit subsampling of the total activity, be it by local averaging (e.g. mesoscopic calcium imaging, fMRI),…

The ability to efficiently and reliably estimate the presence and magnitude of cortical synapses is critical to understanding how synaptic connectivity relates to neural computation, behaviour, and disease. Two-photon optogenetic stimulation paired with whole-cell electrophysiology allows for potential presynaptic…

Color vision represents a vital aspect of perception that ultimately enables a wide variety of species to thrive in the natural world. For humans, a suite of color management tools, developed since the early 20th century and used in our everyday devices, allow for a straightforward investigation of human color vision.…