Pathology ePosters

Wasteosomes (or corpora amylacea) appear in the human brain with advancing age and in some neurodegenerative diseases. They have been proposed to accumulate waste substances and to contribute to a brain-cleaning mechanism. In this context, wasteosomes may have the potential to entrap some of the proteins that misfold,…

Acute Ischemic Stroke (AIS) is a major cause of death and disability worldwide. Mechanical thrombectomy to remove clots from cerebral vasculature represents a unique opportunity to study characteristics and biological patterns of stroke pathophysiology. There is marked heterogeneity in clots and great interest in…

Lead (Pb), a ubiquitous, non-biodegradable heavy metal contaminant, has significant impact on human and animal health. The adverse effect of lead on avian health and productivity has received little attention, considering the fact that they are sentinels. Alchornea laxiflora (Benth), family Euphorbiaceae, grows…

WNT signaling is aberrantly activated in human tumors including gliomas. Promoter methylation and expression of WNT pathway’s negative regulators, DKK1 and DKK3, and positive, GSK3β, together with two signaling antagonists, SFRP1 and SFRP3, were investigated in human gliomas. Gliomas, paired blood and FFPE slides were…

Wasteosomes (or corpora amylacea) appear in the human brain during aging and in some neurodegenerative conditions. They entrap waste substances originated from different cell types and can be released from the brain to the cerebrospinal fluid (CSF). Their presence in the CSF was described using electron microscopy,…

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder characterized by early decline in episodic and spatial memory, associated with accumulation of brain markers. Intriguingly, despite similar levels of brain alteration, some elderly subjects show less cognitive impairment than others. To explain…

The liver, responsible for regulating the metabolism of the body; the kidney, the most important organ for waste elimination, and the spleen, in charge of filtering the blood and producing lymphocytes, are now considered to have clearance functions in Alzheimer’s disease (AD) eliminating Aβ from the brain. In the…

Hydrocephalus is associated with raised intracranial pressure (ICP) and has been implicated as the cause of endocrine dysfunction. Raised ICP results in distension of the third ventricle leading to compression of diencephalic structures and the hypothalamic-hypophyseal pathway. In this study, we aimed to assess the…

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by early non-cognitive dysfunctions. Recent studies have reported synaptic alterations in limbic circuits in AD animal models, even before amyloid plaque appearance. The basolateral amygdala (BLA) is a critical region of the limbic…

Focal Cortical Dysplasia IIB (FCDIIB) represents a large variety of cortical malformations associated with abnormal cortical layering and appearance of dysmorphic neuronal elements, often occurring in the frontal cortex. FCDIIB is a common cause of pharmaco-resistant epilepsies and altered local neuronal activity has…

We characterized a novel model of prodromal Parkinson’s disease (PD) induced by inoculating human alpha-synuclein into the olfactory bulb to trigger alpha-synucleinopathy in wildtype mice. Inoculums were obtained from post-mortem human temporal cortex tissues by sucrose gradient fractionation. C57Bl/6J male mice were…

Microglial phenotype during Alzheimer’s Disease (AD) continuum is under debate. At early stages, a protective phenotype with the typical DAM profile would participate in plaque compaction and Aβ degradation. Instead, human AD microglia (HAM) show an enhance aged/degenerative profile, supporting a microglial…

The primary and progressive degeneration of motor system is the main pathogenic process that characterizes amyotrophic lateral sclerosis (ALS), which is a fatal neurodegenerative disease of motor neurons (MN) in the primary motor cortex and spinal cord. Patients’ death occurs in 3–5 years after the diagnosis due to…

Synapse degeneration contributes to cognitive decline in neurodegenerative diseases. We have previously demonstrated synaptic accumulation of pathological alpha-synuclein in synapses in brain tissue from people who died with Dementia with Lewy Bodies (DLB), but whether this occurs in Parkinson’s disease (PD), a…

With age, differentiated cells undergo a progressive erosion of epigenetic landscape and loss of cellular identity. Specifically, epigenetic aging involves H3K27ac depletion at cellular identity genes and their subsequent repression, together with H3K27me3-mediated derepression of developmental genes, normally…

Parkinson’s disease (PD) results in midbrain dopaminergic neuron degeneration and neuronal accumulation of alpha-synuclein (a-syn). The ‘brain-first vs body-first’ hypothesis of PD proposes that a-syn pathology begins in the brain then spreads to the gut, or conversely begins in the gut then spreads to the brain, via…

The major neuropathologic feature of Parkinson’s disease is the presence of widespread intracellular inclusions of α-synuclein known as Lewy bodies. Evidence suggests that these misfolded protein inclusions spread through the brain with disease progression. Changes in synaptic function precede neurodegeneration, and…