Pathophysiology ePosters

Visual gamma entrainment using sensory stimuli (vGENUS) is a promising non-invasive therapeutic approach for Alzheimer's disease (AD), showing efficacy in improving memory function and physiological biomarkers levels in mice and, in perspective, also human patients. However, its mechanisms of action remain poorly…

Interictal epileptiform discharges (IEDs) are brief, sporadic, pathologic electrical bursts in the brains of patients with epilepsy. IEDs represent an important disease biomarker for tracking seizure risk and they also convey direct pathophysiological impacts including on cognitive function. While most work in human…

Parkinson’s disease (PD) has been associated with alterations in neuronal activity in the basal ganglia-thalamocortical network. The motor cortex (M1) is a key node in this network and likely plays a significant role in the expression of impaired movement in PD. Altered neuronal activity in M1 has been reported and…

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by deficits in episodic memory processing and spatial navigation. Especially, the egocentric neural representation of space, which is important for constructing an egocentric cognitive map, is essential for spatial navigation. However, how spatial…

Schizophrenia is a complex disorder known for its positive symptoms: delusions and hallucinations. However, the impact of schizophrenia on function is mostly due to its executive dysfunction. Mechanistically, it is known that the prefrontal cortex (PFC) is dysfunctional in this disorder and that there is a general…

Epilepsy is a chronic neurological disorder characterized by recurrent seizures resulting from abnormal electrical activity in the brain. All experimental models for seizure generation are based on the administration of drugs (e.g. pilocarpine), on artificial increase in the concentrations of extracellular K+ (Ko) or…

Burst-suppression (BS) is a highly structured electroencephalogram (EEG) pattern characterized by alternating periods of high-voltage activity (bursts) and low or flatline activity (suppression). In non-anesthetized adults, BS indicates severe brain pathology, e.g. due to oxygen and glucose deprivation [1]. There are…

Modeling brain dynamics requires addressing processes that span different temporal and spatial scales [1]. This is crucial, when studying phenomena at the circuit level that are consequences of pharmacological or pathological alterations occurring at the single-cell level, such as changes in ionic or synaptic…

Familial hemiplegic migraine type 3 (FHM-3) is a type of migraine with aura, caused by gain-of-function mutations of NaV1.1 [1,2]. This voltage-gated channel is mainly expressed in fast-spiking inhibitory neurons as their dominant Na+ channel. Cortical spreading depolarization, a wave of hyperexcitability followed by…

Among the brain structures affected in Schizophrenia is the hippocampus. In addition to structural changes [1], dysfunctions of the synaptic plasticity have also been observed supporting cognitive impairment [2]. To study these phenomena in depth, we aim to develop and match two models of the pathology, computational…

White matter (WM) tracts shape the brain’s dynamical activity, and their damage (e.g., disconnections) results in functional alterations and cognitive symptoms [1]. Here, we use neural mass modeling to test the in-vivo effects of WM disconnections [2]. We create models of local versus global, and edge versus nodal…

The hippocampus (HC) plays a pivotal role in spatial navigation and memory in the human brain. Place cells, specialised neurons residing within the hippocampus, exhibit selective firing patterns corresponding to specific spatial locations, collectively contributing to the cognitive mapping of the environment. In…

Parkinson's disease (PD), characterized by the absence of dopamine in the striatum[1], is caused by the death of the substantia nigra pars compacta dopamine (SNcDA) neurons in the midbrain. The loss of these autonomously pacemaking[2] neurons is attributed to irreparable damage due to a dysregulation cascade starting…

Excessive capillary flow heterogeneity results in a microcirculatory dysfunction and hinders optimal oxygen delivery into central nervous system (CNS). Irregularities in cellular flow, like dynamic stalls in capillaries is a potential origin of this heterogeneity. Because under systemic inflammatory conditions…

Migraine is a recurrent headache disorder characterized by episodes of acute pain. The overall objective of this work, was to test the hypothesis that the NLRP3 inflammasome is involved in the pathophysiology of migraine and that NLRP3 blockade may represent a novel strategy for migraine management through the design…

Metabolic Syndrome (MetS) and obesity correlate with cognitive impairment, heightening the susceptibility to cognitive decline and dementia. Noteworthy, cognitive impairment exacerbates weight management challenges in MetS, giving rise to a "cognitive decline-MetS" loop. Indeed, various cognitive and affective…

The proportion of aged individuals in the general population is increasing, and non-communicable diseases like obesity are major contributors to mortality in older individuals. The WNIN/Ob obese rat exhibits a significantly reduced average lifespan of 15 months. Exploring molecular and biochemical characteristics of…

Acute Ischemic Stroke (AIS) is a major cause of death and disability worldwide. Mechanical thrombectomy to remove clots from cerebral vasculature represents a unique opportunity to study characteristics and biological patterns of stroke pathophysiology. There is marked heterogeneity in clots and great interest in…

The striatum is densely innervated by midbrain dopamine (DA) neurons but also receives a further sparse monoaminergic innervation by raphe serotonin (5-HT) neurons. Striatal 5-HT has been suggested to have some opposing functions to DA but also to regulate DA release which might support (or counteract) this functional…

Dementia, a complex, incurable clinical syndrome marked by progressive cognitive decline, encompasses various types, with Alzheimer's disease (AD) being the most prevalent. The annual increase in AD cases underscores the urgency for innovative antidementia treatments. Mansorin A (MA) and mansonone G (MG) exhibit…

The role of dysregulated gut microbiota (GM) is widely recognized as relevant to the pathogenesis of Parkinson's disease (PD), particularly in case of non-motor symptoms such as depression and anhedonia. Most transgenic mouse models of PD, however, don’t exhibit clinically relevant dysbiosis. Here, for the first time,…

Objectives: We aim to investigate the impact of acute stroke on delta oscillation in STN and to explore the correlation between motor disability and the altered delta oscillation in STN following stroke. Methods: 10 Sprague-Dawley rat were included in this study. They were trained in single pellet reaching task before…

Oxidative stress and neuroinflammation are crucial phenomena in the pathogenesis of Alzheimer disease (AD). Oxotremorine-M (Oxo), a non-selective muscarinic acetylcholine receptors agonist, exerts neurotrophic functions in primary neurons and modulates oxidative stress and neuroinflammation phenomena in rat brain.…

OBJECTIVE: Alzheimer's disease (AD) stands as the prevalent neurodegenerative condition globally, characterized by symptoms such as memory loss, language difficulties, disorientation, diminished motivation, self-neglect, mood fluctuations, and behavioral challenges. Despite its widespread impact, the precise cellular…